Aim. To study the clinical features of the course and new approaches to the treatment of intrauterine viral and bacterial infections in newborns.Materials and methods. Clinical features of the course and new approaches to the treatment of intrauterine viral and bacterial infections in 98 newborns were studied based on the state institution of the National Medical Center of the Republic of Tajikistan “Shifobakhsh” in the Department of neonatal pathology.Results and discussion. We examined 98 patients with intrauterine viral and bacterial infections, which made up the main group, and 20 patients of the control group of the study. The diagnosis of intrauterine viral-bacterial infections of newborns was verified based on serological and immunological, clinical, biochemical, and bacteriological studies of blood and loci.Conclusion. The use of specific therapy in combination with metabolic agents and immunocoregulatory therapy in patients with intrauterine viral and bacterial infections leads to a faster positive dynamic of the main clinical manifestations of the disease.