2-Imino-2H-chromene-3-carbo(thio)amides are considered versatile compounds because of their significance as building blocks in synthetic chemistry. In this review, we display the all available synthetic methods for 2-imino-2Hchromene- 3-carbo(thio)amides as well as their reactions towards the different reagents. The presence of the imino and amide groups in these compounds, make C-4 as the only reactive site of the pyran ring with a unique reactivity which could react with different reagents. The appropriate applications about the synthesis of condensed chromene derivatives and their relevancy are reported. The reactions of 2-imino-2H-chromene-3-carbo(thio)amides were divided into several categories depending on the used reagents in the reactions.