Context: Since learning guitar and playing it requires repetitive use of muscles, very often with poor posture, guitarists are at an increased risk of nerve or musculoskeletal damage. As playing is the work of musicians, playing-related musculoskeletal disorders (PRMDs) are an appropriate music-specific derivative of work-related musculoskeletal disorder. Since learning guitar and playing it requires repetitive use of muscles, very often with poor posture, guitarists are at an increased risk of musculoskeletal disorder. Aim: To estimate the prevalence of playing related musculoskeletal disorder among non-professional guitar players. Methodology: it was a cross-sectional study done on non-professional guitar players in the age group of 18-30 years. Modified Nordic Questionnaire was used to screen for the symptoms and a self prepared validated questionnaire was used to take the details of playing related activities. Statistical analysis: Results were analyzed using descriptive statistics. Results: The neck and lower back were reported to be most affected with symptoms of pain (29% each) among the selected population, followed by the wrist (17%) and shoulder (15.5%). The main contributing factor was found to be awkward sitting posture and non-use of back support while sitting.