Obesity is a chronic metabolic disorder that is raised by multiple biological and environmental factors. The objective of this study was to determine the thermogenesis potential of Egyptian Moringa oleifera against obesity disorder. Adult male Wistar albino rats (150-170g) were randomly divided into four groups (10 animals each) as follows: group (1) healthy rats fed standard diet and served as control, group (2) animals orally Moringa oleifera extractstandard diet (20%), group (3) obese rats fed high-fat diet and group (4) obese animals administrated Moringa oleifera extracthigh-fat diet (20%). After six weeks of feeding, the results revealed that feeding of obese animals on moringa (20%) mixed diet succeeded to decline the body weight as well as obesity-induced disorders; this was evidenced by the significant reduction of body weight gain and BMI values as well as levels of serum ALAT, ASAT, urea, creatinine, total cholesterol, triglycerides, LDL, LDH, CK, PON1, TNF-α and glucose. Also, cardio-hepatic MDA and nitric oxide levels ware decreased coupled with marked elevation in the levels of serum HDL and irisin as well as cardio-hepatic GSH, SOD and CAT. Moreover, the histopathological findings showed a marked regeneration. In conclusion, Moringa oleifera, as a food supplement, could play a beneficial role in management of obesity and its disorders; this could be exhibited through its bioactive components with thermogenesis mechanism and/or other multiple pathways.