This paper highlights the powerful combination of reversible addition-fragmentation chain transfer (RAFT) radical polymerization and various click/coupling chemistries. This is not an exhaustive review but rather an overview demonstrating the impressive possibilities that the "marriage" of these two synthetic approaches offers in modern macromolecular design and synthesis.

This review highlights the chemistry of thiocarbonylthio groups with an emphasis on chemistry conducted at v or a and v chain-ends in copolymers prepared by reversible addition–fragmentation chain-transfer (RAFT) radical polymerization. We begin by giving a general overview of reactions associated with the thiocarbonylthio groups, followed by examples associated with macromolecular thiols

A series of thiol-based ‘click’ reactions is discussed with an emphasis on highlighting the individual chemistries and noting recent literature examples. This is not an exhaustive review but rather serves to demonstrate the versatility and clear potential of thiol-based chemistry in polymer/materials design, synthesis, and modification.