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Highlights d Genome-wide CRISPR-Cas9 screens in patient-derived glioblastoma stem cells d Identification of regulators of stemness governing glioblastoma stem cell growth d Multiple stress response pathways are genetic vulnerabilities in glioblastoma d Identification of modulators of sensitivity to standard of care chemotherapy

Highlights d Hypoxic microenvironment is essential for propagation and growth of PFA ependymoma d Hypoxia controls metabolic intermediates that maintain an H3K27 hypomethylated genome d Inhibition or potentiation of histone lysine methylation diminishes PFA survival d Gliogenic lineage of developing fetal hindbrain mirrors PFA metabolic alterations

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Playing it cool: The mass‐analyzed threshold ionization (MATI) spectrum of jet‐cooled cobaltocene shows a surprisingly rich vibronic structure which provides high‐resolution adiabatic (Iad.) and vertical (Ivert.) ionization energies of the neutral molecule, as well as vibrational frequencies of the gas‐phase cation. The spectrum is indicative of both Jahn–Teller (JT) and pseudo‐Jahn–Teller (PJT) activity in the 19‐electron [Cp2Co] sandwich complex.