The IPOM rabbit model is suitable for investigation of biomaterials in the intra-abdominal position. Our results show that the adhesive potential is significantly influenced by the pore size. However, the extent of the foreign-body reaction seems also to be influenced by the filament structure, respectively, the surface area, favoring monofilament material.

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Large-pore PP and co-PVDF-meshes showed comparable good results in the intra-abdominal position, with a reduced inflammatory tissue reaction for co-PVDF. Large pore meshes should be considered an alternative for the development of intraperitoneal onlay meshes.

Phospholipids and icodextrin were effective in preventing re-formation of adhesions.