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The present study was carried out to evaluate antiulcer activity of hydroalcohol extract of Momordica dioica Roxb. fruit. Momordica dioica Roxb. fruit extract (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 days for prevention from ethanol, cold-restraint stress and pylorus ligation-induced ulcers. Estimation of H+-K+ ATPase activity and gastric wall mucous were performed in ethanol-induced ulcer model, antioxidant enzyme activities was carried out in cold-restraint stress-induced ulcer model, and various gastric secretion parameters like volume of gastric juice, acid output, and pH value were estimated in pylorus ligation-induced ulcer model. A significant reduction in lesion index was observed in ulcer-induced animals pre treated with extract at different doses when compared with ulcerated rats in all models. A significant decrease occurred in the level of H+-K+ ATPase, volume of gastric juice, and acid output. Gastric wall mucus and pH were increased significantly. These showed dose-dependent action of extract. LPO and antioxidant enzyme levels of SOD were decreased, but CAT enzyme showed significant increase. Thus the results indicate that the Momordica dioica extract possess antiulcerogenic effect, that attributable to augmentation of gastric defense mechanisms.

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Purpose:Eclipta alba Linn. (Asteraceae) is used traditionally in Indian system of medicine as anti inflammatory, hepatoprotective, hypoglycemic, immunomodulator, in wound healing, and as a potent hair growth promoter. The study was aimed to evaluate the antisecretory and gastroprotective effects of 50% ethanol extract of Eclipta alba.Method:Eclipta alba extract (EAE) at 50, 100 and 200 mg/kg was administered orally, twice daily for 5 days to prevent from, cold restraint stress (CRS), and pylorus ligation (PL) induced ulcers. Antioxidant studies were performed in CRS induced ulcer model. Gastric wall mucus and secretion parameters like volume of gastric juice, acid output and pH were estimated in PL induced ulcer model. Ranitidine (50mg/kg, p.o.) was used as positive control for comparison.Result:A dose dependent and significant (p < 0.05) reduction in lesion index was observed in ulcer-induced rats treated with EAE at various doses when compared with control group in both the models. Gastric wall mucus production was significantly (p < 0.05) elevated in EAE treated rats. Significant attenuation in lipid peroxidation, superoxide dismutase activity was observed, whereas, catalase enzyme levels were elevated in EAE treated groups. Antisecretory activity of EAE was evidenced by significant reduction in gastric volume, acid output and increase in gastric pH when compared to their control values. The findings were further supported by histopathological examination of stomach in both EAE treated and control rats.Conclusion:The results of the present investigation suggest that ethanol extract of Eclipta alba possesses potent antisecretory and gastroprotective activity. The exact mechanism to be evaluated further but in preliminary observation it was thought to be mediated through free radical scavenging activity.