occupying all the left mandibular body also extending to the inferior border. A bone biopsy revealed chronic osteomyelitis and a segment mandibulectomy was performed.Osteomyelitis is an inflammatory condition of bone in which the natural course of the disease is greatly influenced by the patient's overall condition. Team hypothesis was that long-term corticosteroid use could have predisposed to osteomyelitis and even worsened leprosy symptoms, as leprosy symptoms are also reported to increase due to a concomitant infection.