We report a very rare case of renal lymphangiectasia, an accumulation of lymph in the renal lymphatic system secondary to obstruction. Our patient presented to his family doctor for an annual check-up which resulted with high blood pressure and polycythemia. An ultrasound was performed and revealed a large right perirenal collection. A year later, a controlled abdominal computed tomography scan showed a progression and compression of perirenal collection on the right kidney, as well as apparition of a left perirenal collection. Percutaneous drainage of both collections was unsuccessful. Laparoscopy-guided marsupialisation was performed and successful. Blood pressure lowered to normal range without medication. The patient's hemoglobin level decreased within normal range after 3 additional phlebotomies postoperatively.
Materials and methods AnimalsAll procedures performed on horses during the study were approved by the Louisiana State University (LSU) Institutional
Background: Herbal supplements containing curcumin and other ingredients are used for pain management in horses with osteoarthritis (OA). Objectives: To test the effects of a herbal supplement containing curcumin and other ingredients in horses with lameness due to naturally occurring OA. Study design: Two-period randomised crossover design. Methods: Ten Thoroughbreds with naturally occurring chronic OA were randomly assigned to the treatment (BLP; Butelessâ Performance) or control (CTR, no supplement) groups and fed daily for 30 days. On Days À1 (before treatment), 15 and 30, lameness examination, range of motion, pain on palpation and force platform data were collected. Plasma curcumin concentration and its metabolites were measured on Days 1 and 14. Gastroscopy, a complete blood count and a serum biochemistry panel were performed on each horse before treatment Day À1 and Day 31. Gastric lesions (ulcers) were scored in real time by a masked investigator. Results: Mean peak vertical force (PVF), measured by the force platform, significantly increased in the lame limb of the BLP-treated horses on Days 15 (0.40 AE 0.13 N/kg, (p = 0.0025) and 30 (0.63 AE 0.14 N/kg, p < 0.0001) compared to the CTR group. In addition, mean normalised PVF was higher in the BLP group on Day 15 (p = 0.0438) and on day 30 (p = 0.0003) when compared to CTR horses for the same days. The PVF significantly improved (≥5%; range, 5.2-33%) in six of nine individual BLP-treated horses and did not improve (<5%; range, 0-3.4%) in three of nine BLP-treated horses. Also, PVF improved (≥5%; range, 7.6-15.4%) in three of nine horses in the CRT group. Squamous gastric lesion scores significantly decreased in both groups by Day 31. Plasma curcumin-Osulphate concentrations (1.2-3.3 ng/ml) were present in 9/10 BLP-treated horses by Day 14. Main limitations: Small sample size and absence of a positive treatment (non-steroidal anti-inflammatory drug) control. Conclusions: The BLP supplement containing curcumin achieved plasma concentrations and improved weight bearing in some treated horses with naturally occurring OA. Clinical relevance• A supplement containing curcumin and other ingredients fed daily for 30 days improved weight bearing in some of the horses with osteoarthritis by Days 15 and 30 of administration.• Curcumin or other ingredients within the supplement did not cause or worsen non-glandular gastric ulcers.• Curcumin and its metabolite (curcumin-O-sulfate, desmethoxycurcumin) were not present in plasma 2 hours after feeding on Day 1; however, plasma concentrations were found in 9/10 horses after feeding the supplement on Day 14.
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