Non-steroidal anti-in¯ammatory drugs (NSAIDs) and Helicobacter pylori are well-recognized causes of gastroduodenal mucosal damage. This damage is mediated through the effects of both agents on acid secretion, neutrophil activity and function, and prostaglandin metabolism. Clinical trials on the interrelationship between H. pylori, NSAIDs and gastroduodenal mucosal injury have yielded con¯icting results. No consensus has been reached on what recommenda-

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