Variability in the physico-chemical properties of soils affected by animal wastes in Uyo, Akwa-Ibom State, Nigeria was investigated in this study. A free survey technique guided field sampling. Five profile pits were dug on five studied sites namely: Site severely affected with poultry manure, site moderately affected with poultry manure, site severely affected with swine manure, site moderately affected with swine manure, and control site (50 m away from the affected sites). Soil samples were collected at different depths and subjected to routine laboratory analysis. Data collected were analyzed statistically. Results of the investigation showed that variations existed among some physico-chemical properties of soils that are affected with animal wastes when compared to control. There were no variations in the silt and clay content of the affected soil. Among the affected soils, the pH and effective cation exchange capacity decreased down the profile. Results also showed that soils affected with poultry manure and swine manure had the highest exchangeable cations when compared to control. Appropriate measure should therefore be taken in the disposal of these wastes to avoid environmental hazards.