The industrial sector is experiencing an unprecedented number of changes in recent years. New models of remote delivery, especially in complex ICT infrastructures such as healthcare, increase the potential impact of cybersecurity breaches to a level that has not been experienced before. This paper presents the SECurity And privacy protectioN in internet of Things devices (SECANT) project, an EU-H2020 project aimed to strengthen the understanding of risks, at both human and technical level through the delivery of a holistic framework for cyber security risk assessment for enhancing the digital security, privacy, and personal data protection in complex ICT infrastructures, such in the healthcare ecosystem. The SECANT platform will implement a collaborative threat intelligence collection, analysis and sharing, an innovative risk analysis specifically designed for interconnected nodes of an industrial ecosystem, a cuttingedge trust and accountability mechanisms for data protection and a security awareness training for more informed security choices. This platform will be demonstrated and validated across four operational pilots reflecting different real-life business cases.