A small protein was self-assembled on a template. A metal-binding ligand, 4.4-dicarboxylic acid-Z,Z-bipyridine, was attached to the N-terminus of an oligopeptide with the potential to form an amphiphilic a-helix. These bipyridine-modified peptides trimerized to form a three or-helix bundle protein in the presence of FE(ii). The cumulative binding constant was determined to be > 5 x 10'' M-'. approximately 25 times greater than that of a control compound with no peptide moiety. Aldehyde templates are being develoDed to assemble ,.^^..--^I.

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