12 examples) are synthesized from chalcones (I) and evaluated for their biological activity. Some compounds show significant antibacterial, e.g. (IVc), and compound (IIb) shows significant anticancer activity. -(VEKARIYA, N. A.; KHUNT, M. D.; PARIKH*, A. R.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 42 (2003) 2, 421-424; Dep. Chem., Saurashtra Univ., Rajkot 360 005, India; Eng.) -M. Kowall 22-165

An improved environmentally benign procedure for the synthesis of various benzimidazole and benzoxazole derivatives using green solvent PEG400. We have optimized the reaction condition and it was found that PEG400 was believed to be best as compared to PEG200, PEG600 and PEG800 at 80 to 85 °C. This method provides a novel route for the synthesis of benzimidazole and benzoxazole derivatives. The main attractive features of this process are a mild reaction conditions, easy workup procedure and good to excellent yield. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis.

An improved environmentally benign procedure for the synthesis of various benzimidazole and benzoxazole derivatives using green solvent PEG400. We have optimized the reaction condition and it was found that PEG400 was believed to be best as compared to PEG200, PEG600 and PEG800 at 80 to 85 °C. This method provides a novel route for the synthesis of benzimidazole and benzoxazole derivatives. The main attractive features of this process are a mild reaction conditions, easy workup procedure and good to excellent yield. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis.

A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG 400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1 H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.

A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.