No abstract

No abstract

Benzylic-type methyl and methylene groups can be converted either to the corresponding alkyl halide, alcohol or carbonyl compounds by treating different substituted 3-nitro-and 3-alkylaminosulfonylpyrroles with the adequate oxidizing agent.

No abstract

Synthesis and Evaluation of Tacrine-Related Compounds for the Treatment of Alzheimer's Disease.-Friedlaender condensation of cyclic aminonitriles, e.g. (II), with dicarbonyl compounds such as (I), yields the products (IV)-(V). (IV) is a slightly less active inhibitor of acetylcholinesterase than tacrine with much lower toxicity. The structures of the educts (I) and (II) are largely varied as well as their ratio and the catalytic system to give products which have lower potency than (IV). -(AGUADO, F.; BADIA, A.; BANOS, J. E.; BOSCH, F.; BOZZO, C.; CAMPS, P.; CONTRERAS, J.; DIERSSEN, M.; ESCOLANO, C.; GOERBIG, D. M.; MUNOZ-TORRERO, D.; PUJOL, M. D.; SIMON, M.; VAZQUEZ, M. T.; VIVAS, N. M.; Eur.