In circumstances when the flow velocity of a fluid non-homogeneous, difficulties arise in the application of the familiar indicator dilution equations. These and other relevant relationships have therefore been derived from first principles in order to clarify the conditions in which they may be expected to apply. It is shown that the method of introduction of the tracer into a fluid stream as well as its method of measurement are important factors, and the implications of these results for biological measurements are discussed. Illustrations are provided of the indicator dilution curves which are likely to be obtained under conditions of laminar fluid flow in a straight tube and when the diffusion of the tracer can be neglected.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.