Ring closure reactions O 0130Synthesis and Antimicrobial Activity of Some New Cyanopyridine and Cyanopyrans Towards Mycobacterium tuberculosis and Other Microorganisms. -A series of 9 compounds of each type (III), (V), and (VI) is prepared. Some of them show moderate antitubercular or antimicrobial activities. -(VYAS, D. H.; TALA, S. D.; AKBARI, J. D.; DHADUK, M. F.; JOSHI, K. A.; JOSHI*, H. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 6, 833-839; Dep. Chem., Saurashtra Univ., Rajkot 360 005, India; Eng.) -M. Bohle 42-024

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A simple, efficient and modified Biginelli procedure was carried out for the synthesis of tetrahydropyrimidines 4a-o by a solvent-free and catalyst-free condition, by the condensation of 1,3-dicarbonyl compound 1, arylaldehydes 2 and urea/thiourea 3. Neat reactants subjected to microwave irradiation gave the required products more quickly and in better yield in comparison to traditional methodologies. The observed yields and improvement in reaction rates are due to the solvent free conditions coupled with the use of microwave radiation.

Pyrimidine derivatives R 0510 Synthesis and Biological Study of Oxopyrimidines and Thiopyrimidines of 2-(2,4-Dichlorophenyl)imidazo[1,2-a]pyridin-3-carbaldehyde. -A variety of new title compounds (III) (24 examples) is synthesized and evaluated for antimicrobial and antifungal in vitro activities. -(LADANI, M. J.; TALA, S. D.; AKBARI, J. D.; DHADUK, M. F.; JOSHI*, H. S.; J. Indian Chem.