A chloroquine modification of the fluorescent antiglobulin technique has been
used to demonstrate cell-specific antibodies in the presence of HLA antibodies. This is of
particular value in the diagnosis of alloimmune neonatal thrombocytopenia and neutropenia,
post-transfusion purpura, and in the investigation of febrile non-haemolytic transfusion
reactions and of patients refractory to platelet transfusions.
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