Despite its synthetic relevance,
ozonolysis is still an underused
reaction in the synthetic chemistry industries. This can be attributed
to safety issues while handling the ozone itself, alongside extra
hazard related to unstable reaction intermediates. Flow chemistry
is inherently safer as it involves a small volume of reagent at any
given time. Here, to address safety and technical issues, we describe
the design and testing of an ozone dosing line. A global risk assessment
and the description of the setup, the analytics, are presented in
detail. This new dosing line enabled the successful scale-up of β-pinene
ozonolysis in flow, with a productivity of over 16 g/h.
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