The purpose of the study is to study the influence of different vitamin-mineral supplement “Tekro” doses on biochemical parameters in blood plasma and liver of rabbits of New Zealand breed. The research methodology is based on research according to generally accepted research methods. Biochemical parameters were studied in rabbits’ organisms at 45, 60, 75 and 90 days of rearing with feeding of different doses of vitamin-mineral supplement “Tekro”, namely 3 %, 3.5 %, 4 %. The academic novelty is that nowadays the problem of the effect of different vitamin-mineral supplement “Tekro” doses on biochemical parameters in the blood and liver of rabbits has not been studied. Analyzing the indicators of the total protein content in the blood plasma of rabbits of the experimental groups and the control one for 90 days, it was noted that there was no significant difference in the indicators. In the liver of rabbits of the age from 45 to 90 days there was a tendency to increase the protein content due to the effects on the body of various doses of vitamin and mineral supplement “Tekro”. It has been established the positive effect of vitamin-mineral supplement “Tekro” on ALT activity of rabbits in experimental groups. At the age of 75 days, significantly higher ALT activity was recorded in rabbits of the 3rd experimental group by 35.8 % compared to animals in the control group.

Recently, scientific approaches to the classification of the antioxidant system by the mechanism of free radical peroxidation have emerged. This classification of antioxidants is based on the metabolic link to which the action of the antioxidant itself is directed. Therefore, the study of the effect of vitamin and mineral supplements on the indicators of antioxidant protection in farm animals is becoming increasingly important. The aim of this work was to study the effect of different doses of the vitamin-mineral supplement "Tekro" on the biochemical parameters of the New Zealand White breed rabbits. Scientific and economic experience on the topic of work and production verification were carried out on clinically healthy New Zealand White rabbits. The animals were fed with complete feed. Access to food and water was free. To conduct research on the farm, 4 groups of animals were formed: 1 control group, whose animals consumed the basic diet (RR); 2 research – OR with the content of vitamin and mineral supplements (VMS) "Tekro" 3.0%; 3 research – OR with the content of VMS "Tekro" 3.5%; 4 research – OR with a content of VMS "Tekro" 4.0%. The activity of antioxidant enzymes and the content of ceruloplasmin in the blood plasma and liver of rabbits were determined on the 45-th, 60-th, 75-th and 90-th days. In the blood plasma of rabbits from the control and experimental groups, a change in the activity of antioxidant defense enzymes was established. The obtained research results showed that long-term use of the vitamin-mineral supplement "Tekro" significantly positively influenced the antioxidant defense system of the animal body. The established changes in the indicators of antioxidant protection indicate the tension of balancing the prooxidant-antioxidant system of young rabbits. In particular, this phenomenon can be explained by the age-related characteristics of the formation of the antioxidant system of the growing organism of the New Zealand white breed rabbits under the influence of the vitamin-mineral supplement "Tekro". This phenomenon may be evidence of the stabilization of antioxidant processes in the blood plasma of rabbits of the experimental groups as a result of the complex effect of the optimal dose of biologically active substances of the vitamin and mineral supplement. Prospects for further research consist in a detailed study of the effect of various doses of the vitamin-mineral supplement "Tekro" on protein metabolism in the rabbit's body.