This experiment was conducted at the Federal University Dutsin-Ma Livestock Teaching and Research Farm in Dutsin-Ma Local Government area of Katsina State, Nigeria. The study was aimed at studying haematological tolerance level of Uda rams to a rumen fistulation protocol involving incision of skin and muscles separation along the direction of muscle fibers by divulsion. Blood samples were collected and evaluated at the intervals of 0, 24 and 48hours to assess blood line response to the protocol. A total of 3 rams were used and assigned T1, T2 and T3 in a completely randomized technique. A significant (P< 0.05) continuum of decreased packed cell volume and haemoglobin concentration was observed from 0hrs through to 48hours connoting anaemia condition associated with the rumen fistulation protocol. However, significant (P < 0.01) tolerance levels were observed with the cell mediated immune response as evident in the increased lymphocyte counts (lymphocytosis) and an initial acute increase in neutrophils (neutrophilia). This technique was able to demonstrate good tolerance level to rumen fistulation by Uda rams making this breed a good candidate for nutritional and physiological studies requiring rumen fistulation.