Efecto de ciclofosfamida sobre el metabolismo de los hidratos de carbono en glándula submandibular de ratasEffect of cyclophosphamide on the metabolism of carbohydrates in the submandibular gland of rats AbstractObjective: During the period of chemotherapy, the appearance of serious systemic toxicities is one of the main clinical problems, among which are those related to the stomatognathic system. Cyclophosphamide is a drug widely used in solid tumors and bone marrow transplantation. The objective of this work was to evaluate the toxicity of cyclophosphamide on the functional activity of the submandibular glands of Wistar rats in an experimental model. Methods: We used 42 male Wistar rats aged 3 months, housed in individual cages, with temperature and controlled lighting and free diet. They were divided into three experimental groups: 1) Control (C), 2) treated with cyclophosphamide (Cf,) applying an i.p. of 50 mg / Kg of body weight during two consecutive days and 3) rats with paired feeding (AA): during two days the amount administered resulted from the average of the ingested food of group 2 .Both submandibular glands were removed. The submandibular glycogen concentration was analyzed in initial time (t0) and after 60 minutes of mechanical stimulation (t60). Results: The average variations changed significantly between time 0 and 60 in groups C and AA (p-value = 0.0001), Cf had a lower average concentration in time 0 with respect to C and AA, without significant consumption in time 60. Conclusion: Cf would affect the metabolism of carbohydrates, decreasing the use of glycogen as a metabolic substrate. In the present experimental model the toxicity of this drug reduces the functional activity of the submandibular gland.