Chromatographic separation and purification of monohydroxyphenols in vanilla extract were studied. Various methods of separation, concentration, and purification were employed. Millon's reagent, used as a spray, reacted with monohydroxyphenols on the paper chromatogram, producing colored compounds which facilitated their identification and estimation.
The study was aimed at developing a topical preparation of Celecoxib, a COX inhibitor available in oral dosage form only, for localized and systemic effects. Initially, celecoxib containing microemulsion was developed using liquid paraffin, tween 20, water, methyl paraben, propyl paraben, menthol and clove oil. These components were incorporated into Carbopol 934 gel, with varying ratio to achieve stable emulgel formulation. The emulgel appeared as smooth white homogenized formulation having pH 6.6-6.8. The rheological properties showed pseudo plastic nature with yield stress. The spreadability and extrudability showed sufficient consistency for ease of processing, filling and application. Microbial assay showed no contamination to ensure the stability of formulation upon storage. Ex-vivo bio-adhesive strength and skin irritation test showed no irritation on rat skin. All these parameters suggested that emulgel can be explored and developed as an effective alternative formulation for the local and systemic application of celecoxib. various body tissues, connected by blood circulatory system. Another name for non-compartmental analysis is model-independent approach that means it does not require any compartment model.
Sustained release matrix tablets of venlafaxine were formulated using synthetic polymers (ethylcellulose & hydroxypropyl methylcellulose). Six (06) different batches of matrix tablets of venlafaxine (dose 75 mg) were prepared by the wet granulation method. Polymers were used alone or in combination. The physical properties of compressed tablets were evaluated. In vitro release drug studies were performed in phosphate buffer at pH 6.8 over 24 hours. The drug release data fitted well to the First-order (R2 = 0.9725 � 0.9900). The n value obtained for most batches ranged from 0.523 to 0.946 indicates that the drug is released through an anomalous or non�Fickian transport. Results revealed that the combination of ethyl cellulose (EC) and hydroxypropyl methylcellulose produced a sustained effect compared to hydroxypropyl methylcellulose alone. Formulation F6 containing single polymer (EC) showed the highest control over initial burst release, and extended-release of the drug continued up to 16 hours.
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