Relationship between lipid levels and BMI was investigated in euthyroid, hyperthyroid, hypothyroid, general Type 2 diabetics, and non-diabetic control subjects. FT 4 , T 4 , T 3 and TSH did not differ in obese and non-obese diabetics but were higher in diabetics than in non-diabetics (p = 0.015, 0.012, 0.0164 respectively). Levels of FT 4 correlated with TC,

No abstract

Plasma fibronectin levels in sickle cell anaemia and apparently healthy Nigerians were investigated to determine any correlation with disease severity. A cheaper in-house plasma fibronectin assay was also developed that could be adapted for use in Africa and elsewhere. Plasma fibronectin assay was concurrently carried out using the newly developed inhibition enzyme-linked immunosorbent assay (ELISA) and a commercial competitive binding ELISA. The in-house assay compared favourably with that of the commercial kit. The mean plasma fibronectin levels in sickle cell anaemia subjects were significantly lower than that of control subjects (P < 0.001). Plasma fibronectin concentration could therefore be useful in assessing the severity of sickle cell anaemia.

No abstract

Summary. Plasma fibronectin levels in sickle cell anaemia and apparently healthy Nigerians were investigated to determine any correlation with disease severity. A cheaper in-house plasma fibronectin assay was also developed that could be adapted for use in Africa and elsewhere. Plasma fibronectin assay was concurrently carried out using the newly developed inhibition enzyme-linked immunosorbent assay (ELISA) and a commercial competitive binding ELISA. The in-house assay compared favourably with that of the commercial kit. The mean plasma fibronectin levels in sickle cell anaemia subjects were significantly lower than that of control subjects (P , 0´001). Plasma fibronectin concentration could therefore be useful in assessing the severity of sickle cell anaemia.