Euphorbia serrata latex has initially ingenol-3-palmitate, which by action of silica gel is converted to ingenol-20-palmitate. The former is responsible for the irritant and cocarcinogenic activity of the latex on mouse ear and on mice back skin.

The latex of E. s e g u i e r i a n a , which grows wild near Shahgoli, Tabriz, is reasonably irritant on mice ear experiment and the irritant fraction has yielded parent diterpene ingenol.

The latex of Euphorbia seguieriana NECK, which grows wild near Shahgoli, Tabriz, is reasonably irritant and cocarcinogenic on mouse ear and on mice back skin assays, and from the irritant fraction parent diterpene ingenol bas been isolated.