In this paper, we point out thermodynamical description of ghost dark energy and its generalization to the early universe. Thereinafter, we find expressions for the entropy changes of these dark energy candidates. In addition, considering thermal fluctuations, thermodynamics of the dark energy component interacting with a dark matter sector is addressed. {We will also find the effects of considering the coincidence problem on the mutual interaction between the dark sectors, and thus the equation of state parameter of dark energy.} Finally, we derive a relation between the mutual interaction of the dark components of the universe, accelerated with the either ghost dark energy or its generalization, and the thermodynamic fluctuations.Comment: 11 page