The paper is focused on liberation of indomethacin from gels and the influence of microemulsion´s presence in the system. Liberation of drug was performed in vitro through a semipermeable membrane and drug quantity was determined spectrophotometrically. Our results pointed out that the influence of microemulsion system on drug liberation depends on the gel selection. The presence of o/w microemulsion in the lipophilic gel (aerosil in liquid paraffin) increased the released amount of the drug approximately 50%. The liberation profile of indomethacin is better when the hydrophilic gel (carbopol) was used. Drug was released in higher amounts from hydrophilic gel comparised to the commercial gel. The presence of microemulsion in carbopol gel did not have any significant influence.