The search for new natural non-toxic biologically active substances for animals used to correct and stimulate metabolic processes, and through it the ability to control the growth and animals’ productivity, the state of their natural resistance is the main task of the present. The paper presents study results on the effect of cold-pressed amaranth oil and biologically active additive of humic nature «Humilid» when used simultaneously on the general body condition, growth indicators of laboratory rats, morphofunctional and biochemical parameters of their blood. To achieve this goal, the following tasks were set: – to investigate how cold-pressed amaranth oil affects the metabolic processes in the body of laboratory rats; – to conduct research and analyze the effect of the cold-pressed amaranth oil and a humic nature biologically active substance «Humilid» simultaneous use on the indicators of their homeostasis. To accomplish the tasks, the following research methods were used: physiological, morpho-functional, and blood biochemical analysis in experimental laboratory rats. Sexually mature male white rats of 2 months age were used in the experiment. For the study, three groups of animals were formed. The experiment lasted four weeks, during which the animals of the first experimental group received daily, in addition to the main feed settled amaranth oil in the amount of 0.1 ml per rat, and free access to the drinking water. Rats of the second experimental group in addition to the main feed received settled amaranth oil in the amount of 0.1 ml, and free access to the drinking of 0.005% solution Humilid. It was found that the simultaneous use of cold-pressed amaranth oil and Humilid in laboratory rats had a positive effect on the state of erythron, erythrocytes count increased by an average of 28% (P < 0.001), hemoglobin concentration by 10% (P < 0.05). At the same time in animals the biosynthetic function of the liver improved, the total protein content in the blood significantly increased by 10% (P < 0.05), and the amount of albumin by 25% (P < 0.01). Energy processes in the body of experimental animals were increased, that pointed a decrease in blood glucose levels by 22% (P < 0.05). The obtained data obtained indicates that the simultaneous use of amaranth oil and Humilid had a positive effect on the state of homeostasis and metabolic processes in the body of laboratory rats. Thus for them synergistic action is noted.

The effectiveness of the new humic nature feed additive -«Animal Forte», has been established, depending on its amount on the metabolism of laboratory rats. We used sexually mature male white rats of 2 months age, from which five experimental groups were formed and one intact, with eight animals each. The experiment lasted four weeks, during which the animals of the experimental groups received daily in addition to the main feed 5, 10, 20, 30 and 50 mg of feed additive with its active substance per 1 kg of animal's weight. Morpho-functional indicators (hemoglobin content, hematocrit, red blood cells, platelets, and leukocytes) were determined in EDTA stabilized blood. To define the effectiveness of a new humic nature food supplement, the content of total protein, albumin and globulins, uric acid, urea, creatinine, glucose, and the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT) were measured in blood serum. Red blood cell coefficients were determined by a calculation method: mean erythrocyte volume (MCV); mean erythrocyte hemoglobin content (MCH); mean hemoglobin concentration in erythrocyte (MCHC).A feed supplement at a dose of 10 mg/kg had a greater effect on hematopoietic function, especially on the erythropoiesis processes, namely, the hemoglobin content, the number of RBC, the RBC index -MCV, MCH were increased. Due to this, respiration and oxidation-reduction processes in animal tissue were improved. Usage of a biologically active humic nature substance at a dose of 5 mg/kg of animals weight to a greater extent compared with other options improved the function of liver hepatocytes, increasing its protein-synthesizing property, due to this effect, the total protein and albumin content in the serum of experimental animals were increased. Under the influence of the feed additive on metabolic processes, including the membrane's permeability, in the blood of rats of experimental groups, the level of glucose was decreasing. The positive effect of Animal Forte on the kidneys filtration and excretory properties was also noted, due to which the content of urea and creatinine in the blood of rats was decreased. It has been established that already with a minimal dose of 5 mg/kg of body weight, the feed additive had an effect on animals' metabolic processes.