Acute phase proteins are blood components synthesized by hepatocytes, basic function of which is to defend the organism as part of the immune response to inflammation, trauma, infection, stress, neoplasia. They trigger a complex systemic reaction in order to restore homeostasis recovery of the organism. Proinflammatory cytokines increase their activity in response to the effect of pathogenic microorganisms which are intense stimulants to the production of acute phase proteins. It is known that postpartum uterine contamination is common among many cows. Normally, infections and inflammations are eliminated by the immune response of the uterus. However, about 40% of dairy cattle develop clinical metritis. The aim of this study was to determine changes of C-reactive protein and haptoglobin concentration in healthy cows and with subclinical endometritis. The study was conductedat NNVTS "Komarnivsʹkyy" Horodok district, Lviv region. Two groups of cows of Ukrainian blackand-white dairy breed, aged from 4 to 7 years old, were investigated. The control group included twenty (n = 20) clinically healthy cows. Experimental group included twenty (n = 20) cows with subclinical endometritis. It was found that in the blood serum of healthy cows C-reactive protein concentration was 11,25±1,07 µg/ml. Significant increase (P˂0,001) of C-reactive protein concentration in cows with subclinical endometritis (72,57±18,11 µg/ml) was observed. In the blood serum of healthy cows haptoglobin concentration was 22,5±5,50 mg/l. Significant increase (P ˂0,001) of C-reactive protein concentration in cows with subclinical endometritis (72,57±18,11 µg/ml) was observed. In the blood serum of healthy cows haptoglobin concentration was 22,5±5,50 mg/l. Significant increase (P ˂0,001) of C-reactive protein concentration in cows with subclinical endometritis (72,57±18,11 µg/ml) was observed. In the blood serum of healthy cows haptoglobin concentration was 22,5±5,50 mg/l. Significant increase (P <0,001) of haptoglobin concentration in cows with subclinical endometritis (771,5±122,66 mg/l) was observed. The presented study shows that in cows with subclinical endometritis, increase of C-reactive protein and haptoglobin was observed. Determination of concentration of these proteins can be an informative indicator of subclinical inflammatory process in the uterus of cows. In future research it is important to determine change of IL and TNF-a expression depending on the condition of the uterus. Key words: acute phase proteins, C-reactive protein, haptoglobin, subclinical endometritis, dairy cattle, uterus.

Among diseases of the reproductive organs of bitches, pyometra is most often registered. Objective diagnosis of this disease in dogs by practicing veterinarians is difficult and uninformative. In addition, to date, effective methods of treatment for pyometra, which allow for restoring the productivity of the animal, have yet to be sufficiently developed. The purpose of the research was clinical trials of an antibacterial drug based on amoxicillin trihydrate, which is used for the medical treatment of pyometra in bitches – “Amoksidev 15”. The research was conducted on purebred and purebred bitches treated in the clinic with a pyometra (empyema) diagnosis of the uterus. Conservative treatment of bitches, using the antibacterial drug “Amoksidev 15” as part of a complex scheme, which included the following drugs: Dinolytic (enzaprost-F), No-shpa, Devivit Complex, Tioprotectin 2.5 %, herbal decoctions (nettles, raspberries, chamomile, boar's uterus) led to the recovery of 70 % of sick animals. When using drug therapy (animals of the control group), the clinically expressed manifestation of the disease lasted eight days on average. In the blood of these animals, an increase in the number of erythrocytes by 23.2 % was observed, and the number of leukocytes increased by 39.0 %. Therefore, the complex therapy used in the experiment resulted in the faster restoration of the reference values of the body's physiological indicators than in the control group animals, which included Enroxil 5 % as part of the complex therapeutic scheme. The prospect of further research will be clinical trials of the antibacterial drug “Amoksidev 15” in complex therapy for treating pyometra in cats.

This article describes the results of the study of the prostate gland of dogs and changes in the level of sex hormones when treated with Suprelorin 4.7 mg implanted subcutaneously in the shoulder region. Suprelorin is an innovative drug that limits the production of testosterone. His action can be compared with the results of castration, but the owners of the animal provide their dog and, in fact, themselves, with the lack of stress and various problems associated with surgical intervention. Suprelorin is a non-steroidal, peptide contraceptive in the form of an implant. The active ingredient is deslorelin (an agonist GnRH), which inhibits the reproductive function at the level of the hypothalamic-pituitary axis for at least 6 months. Deslorrelin is a synthetic analogue of GnRH less susceptible to decomposition, seven times more potent than endogenous GnRH, more stable, and also with a higher sensitivity to GnRH receptors. GnRH plays a key role in controlling the reproductive system of females and males. And in the case of long-term prescribing of small doses of deslorelin, inhibition of functioning of the pituitary gonadal axis occurs. The central place in which the blocking of the synthesis and / or allocation of follicle stimulating (FSH) and luteinizing hormones (LH) in the dogs, which was introduced implant. In this case, there are no side effects of steroid. When conducting diagnostic measures with the help of an ultrasound machine, the tasks facing the specialist are: to determine the shape, size and echostructure of the prostate gland, its contours and capsules. According to the results of the ultrasound, experimental groups of animals and control were formed. The criterion for the formation of experimental groups was the increase the size of the prostate and structural changes (increasing or decreasing echogenicity, hypo-and anechoic inclusion in the parenchyma) in it. In the examination of dogs by ultrasound, it was found that the animals in the control group of the prostate were normal, and in animals of the experimental group were found structural changes in it, in particular, increase the size of the gland, increase echogenicity and heterogeneity of the structure of the parenchyma, anechoic inclusions of various sizes. While assessing the level of hormones in dogs, there was a significant decrease in testosterone levels in the experimental group, as well as an increase in the level of estradiol, luteinizing hormone, thyroid stimulating hormone, and T3 total in blood serum of dogs in experimental groups. The level of hormones was monitored weekly and reflected its changes on the schedule. Libido of all animals under the action of the implant significantly decreased. Behavior became calmer. Appetite improved and activity was normal. The sexual function of the treated dogs was completely restored a year later.