Acute hypocortisolemia and CDI are predictive of mortality and long-term pituitary deficits in TBI.

The most common cause of hyponatremia after acute nontraumatic aneurysmal SAH is SIAD. Acute glucocorticoid insufficiency accounts for a small but significant number of cases. We found no cases of CSWS.

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100 nM), TNF-a (25 ng/ml), IL-6 (50 ng/ml), and soluble IL-6 receptor (sIL-6R, 250 ng/ml). In Study 1A, bovine disks (N ¼ 6 per group and time point) were incubated with IL-1a with or without Dex for a period of 8, 16 or 24 days. In Study 1B, bovine disks (N ¼ 6 per group) were incubated with IL-1a for the first 8 days, and then switched to cytokine-free medium for another 8 days; Dex treatment started on either Day 0 or Day 8, and continued until Day 16. In Study 2, human knee disks (N ¼ 9 per group) were treated with the combination of TNF-a, IL-6, and sIL-6R with or without Dex for 17 days. In Study 3, human ankle disks (N ¼ 6 per group) were incubated either with IL-1a or the combination of TNFa, IL-6, and sIL-6R with or without Dex for 17 days. Disks were stained