Highlights A methodology for obtaining EHR-derived datasets for COVID-19 research is proposed. It allowed effective reuse of EHRs in a tertiary Hospital during COVID-19 pandemic. ISARIC-WHO COVID-19 CRF was obtained for 4,489 patients with high coverage. Detailed Clinical Models provides the flexibility needed to expand the concept model. ISO 13606, SNOMED CT and LOINC standards were used for modeling and standardization.

Due to a progressive increase in the use of chemotherapeutic agents an increased incidence of hypersensitivity reactions is to be expected. Desensitisation protocols are a noteworthy alternative that make it possible to re-initiate patients' therapy with the causative agent of the hypersensitivity reaction. Their use should be assessed individually, weighing risks and benefits.

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