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TEC(Millions/µL) TLC(Thousands/ µL) DAY 14 DAY 28 DAY 14 DAY 28 G1 9.15±0.06 d 9.12±0.04 d 15.55±0.12 d 15.48±0.10 d G2 5.82±0.02 a 5.08±0.05 a 11.50±0.12 a 10.51±0.13 a G3 9.28±0.07 d 9.30±0.02 d 15.55±0.11 d 15.56±0.11 d G4 9.22±0.05 d 9.25±0.08 d 15.57±0.08 d 15.58±0.05 d G5 6.78±0.18 b 6.84±0.10 b 12.57±0.06 b 13.02±0.12 b G6 6.51±0.12 b 6.74±0.18 b 12.59±0.07 b 13.09±0.16 b G7 7.16±0.09 c 7.77±0.14 c 13.40±0.08 c 13.96±0.11 c Values are Mean±SE (n=6); One-way ANOVA Means with different superscripts in a column differ significantly at P<0.

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The present study aimed to investigate the protective effect of ascorbic acid on paraquat induced serum biochemical alterations in experimental rats. Forty-eight (48) male albino Wistarrats were randomized into four (4) groups consisting of twelve (12) in each. Group 1-Control. Group 2 -Paraquat at the rate of 40 mg/kg b.wt. Group 3 -Ascorbic acid at the rate of 250 mg/kg b.wt. Group 4 -Paraquat at the rate of 40 mg/kg b.wt + Ascorbic acid at the rate of 250 mg/kg b.wt. The treatment regimens were administered by oral gavage once daily for twenty-one (21) days. Significantly (P<0.05) increased activity of aspartate transaminase, alanine transaminase, alkaline phosphatase, blood urea nitrogen and serum creatinine and significantly (P<0.05) decreased activity of total protein was observed in group 2 on 7 th and 21 st day of experiment. Cotreatment with ascorbic acid showed a remarkable protection against the parameters investigated possibly via antioxidant defence mechanism.