Melanoma is one of the most frequently metastasizing malignant neoplasias. This study examines an experimental model of pulmonary metastasis and the B16F10 cell subline, highly metastatic in the lung. Antimetastatic effects of the flavonoids tangeretin, rutin, and diosmin were analyzed, and at the same time an analysis of the metastatic activity of ethanol was performed, considered to be necessary because it is used as a vehicle for administering the flavonoids. Lentini's model, which complements the macroscopic evaluation of nodule numbers by using a stereoscopic microscope and image analysis at the microscopic level, was used. The greatest reduction in the number of metastatic nodules (52%) was obtained with diosmin; similarly, the percentages of implantation, growth index, and invasion index (79.40, 67.44, and 45.23%, respectively), were all compared with those of the ethanol group, considered to be an effective control group. Rutin- and tangeretin-treated groups also showed reductions of the same index compared with the ethanol group. It would seem that structural factors would better explain these results and the antimetastatic activity of each flavonoid and the respective metabolites.

Ethanol administration significantly increased pulmonary metastasis while grape-seed extract and red wine led to their reduction.

Le logement social abordable pour aînés relève d’une politique d’appui aux personnes âgées les plus vulnérables, avec le soutien à domicile et les régimes publics de retraite. Le vieillissement de la population accroît cependant le coût de ces services et les administrations publiques au Québec hésitent à les développer. Conséquemment, à Montréal, le logement social abordable pour aînés souffre d’un déficit de places, l’Office municipal d’habitation de Montréal et la Société d’habitation du Québec devant composer avec ces limitations de ressources. Pourtant, le logement constitue le besoin prioritaire pour les personnes âgées alors que nous constatons la prépondérance grandissante du secteur privé.

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