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This study focuses on the knowledge, attitude and practice of vaccination among parents in an Indian rural community. The researcher was used descriptive research and survey design for the study. The universe of the research was total number of parents in malappuram district. The researcher used purposive sampling as sampling method. Sample size was 102. The researcher used semi structured survey design for collecting data. It includes; Socio- Demographic Profile of the respondents and semi structured questionnaire includes knowledge, attitude and practice of the respondents regarding vaccination .The study-findings reveals that there are vaccination campaigns and anti-vaccination campaigns are conducting in malappuram district. The parents are aware about vaccination, even though most of them are not ready to practice it.