The molal solubility for nano zinc oxide (ZnO) , copper (2%) doped ZnO , Fe(2%) doped ZnO , Ti(2%) doped ZnO , Ag (25) doped ZnO in 50%DMF and 50% DMSO, (v/v), volume to volume were measured at 293.15, 303.15 , 313.15, 323.15K . The thermodynamic parameters, Gibbs free energy of solvation, enthalpies and entropies of solvation were evaluated for nano zinc oxide and nano zinc oxide doped from the solubility measurements. These thermodynamic parameters explain the effect of doping elements on the thermodynamic behviours of nano zinc oxide in solvation process. Contribution/ OriginalityThis paper uses the thermodynamic parameters for discussing the solubility behaviour because few studies is finding for nano particles solvation explanation.Optical, electrical and mechanical properties, which results with their quantum confinement effects compared with their bulk counter parts. Among various nano semiconductor, zinc oxide (ZnO) nano particles are the most frequently studied [3]. Normal ZnO has band gap of 3.37 ev and high binding energy [1,2] and high exciting binding energy 60 eV [3] Application uses of nano ZnO include solar energy [3], varistors [4], luminescence [5]., photo-catalysis [6],electrostatic coating [7], transparent protection films [8] and chemical sensors [9][10][11][12][13][14][15][16]. In particular, zinc oxide has other applications such as gas sensors, blue lasers, short-wavelength light-emitting devices. ZnO belongs to a group of metal oxides that are characterized by their photo-catalytic and photo-oxidizing ability against chemical and Biological species [16][17][18].