Lung cancer remains the most common cancer in the world. The genetic polymorphisms (rs2853669 in TERT, rs1052133 in OGG1, and rs16969968 in CHRNA5 genes) were shown to be strongly associated with the risk of lung cancer. Our study's aim is to elucidate whether these polymorphisms predispose Eastern Algerian population to non-small-cell lung cancer (NSCLC). To date, no study has considered this association in the Algerian population. This study included 211 healthy individuals and 144 NSCLC cases. Genotyping was performed using TaqMan probes and Sanger sequencing, and the data were analyzed using multivariate logistic regression adjusted for covariates. The minor allele frequencies (MAFs) of TERT rs2853669, CHRNA5 rs16969968, and OGG1 rs1052133 polymorphisms in controls were C: 20%, A: 31%, and G: 29%, respectively. Of the three polymorphisms, none shows a significant association, but stratified analysis rs16969968 showed that persons carrying the AA genotype are significantly associated with adenocarcinoma risk (pAdj = 0:03, ORAdj = 2:55).Smokers with an AA allele have a larger risk of lung cancer than smokers with GG or GA genotype (pAdj = 0:03, ORAdj = 3:91), which is not the case of nonsmokers. Our study suggests that CHRNA5 rs16969968 polymorphism is associated with a significant increase of lung adenocarcinoma risk and with a nicotinic addiction.

We want to give a new application of general relativity and precisely the gravitational waves. After studying and developing the explicit lensing and Doppler like effects of the circular polarised mode. A new explanation to the wavy motion of stars known as astrometric binary using the GW is presented and its applicability is discussed.

Abstract.A new simulation code to constrain the cosmological parameters and computes the free electron fraction evolution is presented. The code algorithm, inputs-outputs and possible preliminary results are also discussed.

A Universe containing uniform magnetic fields, strings, or domain walls is shown to have an ellipsoidal expansion. This case is motivated from observational cosmology, especially the anomaly concerning the low quadrupole amplitude compared to the best-fit ΛCDM prediction in WMAP data. It is shown that a Universe with eccentricity at decoupling of order 10−2 can reduce the quadrupole amplitude without affecting higher multipoles of the angular power spectrum of the temperature anisotropy. The evolution of ellipsoidal Universes is studied using dynamical system techniques for the first time. The determined critical points vary between saddle and past attractors depending on dark energy state equation parameter w Λ, with no future attractors. Numerical integrations of this dynamical system done using several initial conditions are showing new important results. For instance, a tendency for high expansion differences between planar and perpendicular axes is observed which contradicts previous assumptions on the evolution behaviour of ellipsoid Universes.