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In this paper, we consider the detection of differential space-time block codes in static Rayleigh fading channels. Conventional diyerential detection (CDD), the most prevalent and most basic approach, suffers from a loss in performance when compared to coherent detection. As an alternative, we propose using the sequence estimate provided by space-time multiple symbol differential detection (ST-MSDD) to initialize an iterative receiver based on the expectation maximization (EM) algorithm. The EM-algorithm performs joint channel estimation and sequence detection. Employing BPSK modulation, simulation results show that the EMbased receiver outperforms standard ST-MSDD receivers afler three iterations. The results in the paper demonstrate that our EM-based coherent receiver, using a non-coherent first-pass. oflers a reasonable performance improvement over standard non-coherent receivers.