The article is devoted to evaluating the effectiveness of transcranial magnetic stimulation in the complex therapy of treatment-resistant depressions complicated by residual organic insufficiency of the central nervous system. For this purpose, a sample of 109 patients with this pathology was randomly divided into a main group (55 people) and a control group (54 people). The patients of the main group received a combination of antidepressants and 12 sessions of transcranial magnetic stimulation according to the iTBS protocol. The patients of the control group received only psychopharmacotherapy with a combination of antidepressants. The patients of both groups were examined at 2 and 4 weeks from the start of treatment, as well as in the catamnesis after 1 month and 6 months after the end of treatment, using BDI, BAI, CGI-S, and CGI–I questionnaires. It has been proved that the complex therapy of treatment-resistant depressions complicated by residual organic insufficiency of the central nervous system with the use of TMS sessions and psychopharmacotherapy is more effective than with isolated psychopharmacotherapy, which was confirmed by a statistically significant more pronounced reduction in the severity of depression and anxiety according to psychometric questionnaires and an improvement of the clinical condition on the CGI–I scale.

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