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The height of the reduction wave is proportional to the concentration of the nitrofuran compound. The logarithm of the heights was plotted against the time in a diagram of the type presented in Figure 1, from which per cent reduced compound after 1 hr reaction could be calculated. The values in Table I1 are the mean values with calculated 95% confidence limits assuming the same variation in measurements with all compounds. skilled technical assistance of Miss A. Notrman and Mr. 0. Hall (Chemistry), Mr. E. Johansson (Pharmacology), and Mrs. E. Olsson and Mrs. A. Enqvist (Microbiology). We also thank Dr. M. Ceska for help with the enzyme preparations and Messrs. R. Anderson and R. Lofstedt for performing the metabolic studies. We are grateful to Mr. A. Lanner for the administration of the clinical trials and to Mr. Goran Nilsson for help with the statistical calculations.

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Aus den Pyridinäther‐ aziridinen (I) entstehen mit Ammoniumthiosulfat die Buntesalze (II), mit Schwefelwasserstoff die Mercaptane (III), die z.Tl. zu den Disulfiden (IV) oxidiert werden können.

Carbonsäuren (I) werden in Tetrahydrofuran mit Lithium‐diisopropylamid zweifach metalliert zu (II) und dann bei Raumtemperatur durch Einleiten von 5 Luft über einen Zeitraum von 14 ‐ 18 Stdn. oxidiert.