Abstract-The pathological role of interferon-␥ (IFN-␥) in atherosclerosis is mediated through effects on macrophages, foam cells, and other vascular cells. Recently, we reported that ATP-binding cassette transporter-1 (ABC1) message and protein levels were decreased 3-to 4-fold in foam cells by IFN-␥. In the present study, the pathway by which IFN-␥ inhibited ABC1 expression was investigated with signal transducers and activators of transcription (Stat1) Web Site FeatureThe full-length article can be found on the World Wide Web at

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