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The main objective of this paper is to investigate an accurate numerical method for solving a biological fractional model via Atangana-Baleanu fractional derivative. We focused our attention on linear and nonlinear Fisher’s equations. We use the spectral collocation method based on the Chebyshev approximations. This method reduced the nonlinear equations to a system of ordinary differential equations by using the properties of Chebyshev polynomials and then solved them by using the finite difference method. This is the first time that this method is used to solve nonlinear equations in Atangana-Baleanu sense. We present the effectiveness and accuracy of the proposed method by computing the absolute error and the residual error functions. The results show that the given procedure is an easy and efficient tool to investigate the solution of nonlinear equations with local and non-local singular kernels.