Hidradenitis suppurativa, also known as acne inversa, is a chronic inflammatory skin disease which affects ~1% of the world population. Hidradenitis suppurativa significantly impacts patients’ quality of life due to its chronic nature and frequently occurring relapses. Therefore, Hidradenitis suppurativa patients need to get an early diagnosis. This study was designed to evaluate the efficiency of Endolift®, a novel minimally invasive outpatient laser procedure, for treating Hidradenitis suppurativa. Thirty patients in the range of 19 to 43 y-o, 20 women and 10 men, were enrolled on this study. Patients have undergone a single treatment under tumescent anaesthesia. Treatment was performed using the Endolift® procedure, consisting of the device Eufoton® LASEmaR® 1500. This device uses a 1470 nm wavelength laser lead by micro-optical fibres of different calibres directly inside the skin. This treatment aims to destroy problematic glands with a thermal effect and remove them with liposuction. The treatment has a strong anti-inflammatory effect and promotes neocollagenesis. Eighteen patients obtained optimal results, 5 had good results, and 7 reported moderate results. The treatment was repeated for 7 patients for small refractory areas. Patients with earlier onset of the disease generally had better results. No side effect was recorded. Endolift® treatment represents a big hope for the patient because it is a safe, effective, minimally invasive procedure and can be repeated.