The use of monolithic catalysts in multiphase applications has received increasing interest throughout the last years. In this paper the use of monolithic catalysts in the hydrogenation of edible oils is studied. In comparative experiments the monolithic catalysts have shown a lower tendency to form trans-fatty acids compared to slurry catalysts with equal composition. It is also demonstrated that the monolithic catalyst could be reused several times without significant changes in the product composition. With respect to the effect of the operating parameters on the performance, common knowledge applies. By using a monolithic-catalyst-based technology, the process complexity can be significantly reduced as the separation of the oil and the catalyst becomes straightforward and the filtration and bleach steps are eliminated. An economic evaluation showed a significant reduction in the product cost when monoliths are used instead of a conventional slurry system.