The atypical hemolytic uremic syndrome (aHUS) is the most complex disease in the diagnosis, treatment and prognosis among the thrombotic microangiopathy. The article describes the clinical case of a 32-year-old woman with an aHUS in 32 week of gestation. It is given the diagnosis and treatment of this case till clinical convalescence.Observation within 1 year after the episode of the aHUS is showing up a chronic kidney failure, which will provide renal replacement therapy in future.

Atypical hemolytic-uremic syndrome being referred to autoimmune diseases appears to be one of the most severe forms of thrombosis and microangiopathy. Difficulties in diagnosis cause a delay in pathogenetic therapy, which causes a high maternal mortality rate. Pathogenetic therapy with eculizumab, suppressing the terminal activity of complement, may contribute to the recovery of blood coagulation properties, but the long-term prognosis for chronic renal failure remains unfavorable. The article deals with a clinical case confirming this conclusion.