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cretion of creatinine, but it may be noted that the aglommlar tubule must excrete its own water, this water moving in the same direction as the excreted solutes. Whether this circumstance imposes a relationship upon the mechanism of transfer which is absent in the glomerular nephron cannot be determined at present. If the transport of creatinine and water are independent functions, it is possible that the concentration of creatinine in the final tubular urine imposes a limitation upon its excretion. There would appear to be no reason to postulate a different mechanism of excretion in the aglomerular and glomerular nephron; but if such a relationship exists in the latter it may not be discoverable since the creatinine is excreted into a relatively large quantity of glomerular filtrate which subsequently undergoes concentration by the tubular reabsorption of water. Pa&, Imtitut A g r m Q w de 1'Etat d Gemblouca.Two of us (J. Basset and M. Macheboeuf) with the help of several coworkers' have submitted different biological samples to the action of an apparatus devised several years ago by Basset' which realizes enormous pressures (beyond 20,000 atmospheres). Non-sporulated bacteria were killed after 45 minutes of exposure to a pressure around 5,OOO atmospheres, while sporulated bacteria resist as high pressures as 20, OOO atmospheres. Certain viruses and bacteriophages, on the contrary, are inactivated at pressures around 3,000-4,OOO atmospheres, while some enzymes are inactivated at about 13,000 atmospheres and toxins at 17,000-19,000 atmospheres. Thus, if toxins behave much like enzymes, bacteriophages behave more like viruses. Globulins are denatured around

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We compared the efficacy and side-effects of continuous infusion versus repeated injections of epMural bupivacaine

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