The high mountains have retained a noticeable degree of wilderness even in the most populated regions of the planet. This is the reason why many nature reserves have been established in these landscapes. Currently, climate change and long-range transport of contaminants are affecting those protected areas, and thus conservation priorities may be challenged by these new pressures. In fact, many high mountains hold a legacy of on-site past human activities (e.g., pasturing, forestry, mining), which in some areas may partially persist, even increase, whereas in others are substituted by new uses (e.g., tourism, mountain sport). Therefore, high mountain nature reserves face a challenging future. The conservation goals have to be revised. Former alternative paradigms respectively based on the preservation of wilderness or a traditional cultural landscape will be insufficient. Indeed, global change provides new goals for the high mountain conservation areas as suitable places where to study the nature's response in the absence of, or combined with, other local pressures. Different branches of sciences may contribute to inform about the changes; however, conservation is ultimately a societal endeavour and thus their goals must be linked to the social demand for a fair society in a sustainable planet. As an added-value to this task, the high mountains hold a large amount of symbolism.