This study aimed at analyzing the spatio-temporal patterns of urban growth and its effects on Rwampara wetland, located in the City of Kigali,  Rwanda. First, the study was based on the application of remote sensing technology, where 4 Landsat images (1987, 1999, 2009 & 2018) were  classified using maximum likelihood classification algorithm. This helped in analyzing the Land Use and Land Cover (LULC) trends in the study area. Secondly, it used the existing LULC data for the years 1990, 2000, 2010 and 2018 in order to investigate the overall changes in LULC in Kigali City. Finally, semi-structured interviews were used to collect data from local people and decision-makers about their past and future management strategies of Rwampara wetland. In this regard, 30 local communities (mainly natives from the study area), 15 local government authorities at sector and district levels as well as 4 senior government authorities in the central administration were interviewed. The findings revealed that over the past 4 decades, urban growth in Kigali City has rapidly increased at the expense of resource degradation in Rwampara wetland. Specifically, there has been an increase of about 77% of the built-up area over the last 31 years (1987-2018) which has led to the decrease of the wetland surface area from 24 ha in 1987 to only 7.7 ha in 2018. The results also revealed that demographic factors (i.e. a high population growth rate and high population  densities) were mainly responsible for urban growth and degradation of wetland resources in the area under investigation. Keywords: urban growth, wetland, wetland resources, wetland degradation, wetland management