Relevance. Ketosis is a frequently observed disease in cattle, which is especially susceptible to highly productive cows after calving, and therefore the search for affordable and effective methods for the prevention and correction of this condition is actively pursued.Materials and methods. The biochemical parameters of the blood serum of Blackand-White cows with subclinical ketosis treated according to schemes that included propylene glycol, natural zeolites of the Khotynets deposit, and lecithin were studied. The biochemical composition of blood serum and the activity of enzymes in it were investigated in 4 groups of newly calved cows: 1 — clinically healthy (control); 2 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days; 3 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days and zeolites in the amount of 3% of the dry weight of the feed for 21 days; 4 — animals with subclinical ketosis which received 250 ml of propylene glycol 2 times a day for 7 days, zeolites in the amount of 3% of the dry weight of the feed and 15 g of lecithin per 100 kg of live weight for 21 days.Research results. It was found that the restoration of the parameters of the biochemical composition of the blood serum of diseased cows to the levels of clinically healthy animals had been achieved on the 22nd day of therapy with the combined use of propylene glycol, natural zeolites and lecithin. The exception was the glucose content, which remained significantly increased by 14.0% compared to the control. The advantage of a complex treatment scheme over the main therapy used on the farm with the use of only propylene glycol is expressed in a significant increase on the 22nd day of the experiment in the blood serum of total protein by 7.0%, urea — by 17.5%, a decrease in cholesterol concentration by 29.0%, total bilirubin — by 27.5%, AST enzyme activities — by 31.9% and LDH — by 28.5%.