The present study involves the eco-friendly naturally coloured cotton DDCC-1 and white cotton yarns which were used to produce pin and medium stripe khadi fabrics and given special bio-finishes viz., enzymatic de-sizing, bio-polishing and silicon softener finish and further tested to know their impact on different structural, performance and durable properties. Multiple linear regressions were used to analyse their influence on one another. It was found that on special finishing, both WC and DDCC-1 yarns became finer and slight increase in cloth count; considerable reduction in bending length; improvement in crease recovery angle and drapability of both the stripe fabrics was observed. Whereas, tensile strength and elongation were reduced; and no considerable change was observed in abrasion and pilling.